What are indications for the use of AXURA?

AXURA is to be used for treating patients with moderately severe to severe Alzheimer’s disease.
Memory loss associated with Alzheimer’s is caused by a disruption in the transmission of brain signals. So-called NMDA receptors in the brain assist in transmission of nerve signals essential to learning and memory functions. AXURA belongs to a group of medications called NMDA receptor antagonists. AXURA stimulates these NMDA receptors and improves transmission of nerve signals and thereby the memory.

What should you consider before taking AXURA?

Prior to taking AXURA, it is important that you carefully read the
following paragraphs and discuss any questions you may have with your doctor. You may wish to go through all the details you would like to
discuss first with your carer.

AXURA must not be taken:

If you have had allergic reactions to memantin hydrochloride or any of the other ingredients of AXURA tablets listed above.

Particular caution is required when taking AXURA:

If you have a history of epileptic seizures
If you have recently suffered a myocardial infarction (heart attack) or if you suffer from under-compensated cardiac insufficiency or untreated high blood pressure.
Under these circumstances treatment must be carefully monitored and the clinical use of AXURA regularly re-evaluated by your doctor.

If you suffer from moderately severe kidney dysfunction, your doctor should carefully monitor your kidney function and adapt the memantin dosage appropriately. The use of memantin is not recommended for patients with severe kidney dysfunction.
Simultaneous use of medications with active ingredients such as amantadine, ketamine, dextromethorphane as well as other NMDA antagonists should be avoided.
The use of AXURA is not recommended for children or anyone under the age of 18.